PURPOSE OF THE STUDY: To study the effect of complex rehabilitation with the inclusion of low-frequency electrostatic therapy on the dynamics of immune status in patients with myocardial infarction (MI) after endovascular myocardial revascularization. MATERIAL AND METHODS: The state of the immune status was studied in 68 patients with MI after percutaneous coronary intervention (PCI) - coronary angioplasty with stenting, admitted to the inpatient stage of medical rehabilitation. RESULTS: The study proved the involvement of the immune system in a complex set of reactions occurring in patients with myocardial infarction after PCI. Significant correlations between biochemical and immunological markers of inflammation and risk factors for cardiovascular diseases have been established. Carrying out complex rehabilitation measures using low-frequency electrostatic therapy at the stationary stage of medical rehabilitation helps to reduce the activity of the inflammatory process and eliminate the immunological imbalance in MI patients after endovascular myocardial revascularization. CONCLUSION: The inclusion of low-frequency electrostatic therapy in the medical rehabilitation complex has a significant immunocorrective effect on the parameters of cellular and humoral immunity, the ratio of pro- and anti-inflammatory cytokines, which justifies the prospects for its use in the rehabilitation of patients with myocardial infarction.
Myocardial Infarction , Percutaneous Coronary Intervention , Humans , Percutaneous Coronary Intervention/adverse effects , Inpatients , Static Electricity , Myocardial Revascularization/adverse effects , Cytokines , Treatment Outcome
The need to expand the resort and recreational potential in the Siberian Federal District is due to the growing need for sanatorium treatment and rehabilitation of the population. Balneological studies conducted in different regions of Siberia make it possible to position these territories as promising for resort and recreational activities. OBJECTIVE: Comprehensive integral assessment of the resort and recreational potential of the treatment areas of the Republic of Tyva. MATERIAL AND METHODS: Taking into account the requirements of the guidelines "Bioclimatic passport of the medical and recreational areas" No. 96/226, approved by the Ministry of Health of Russia on February 7, 1997, an integral medical and climatic assessment of the territories of the medical and recreational areas of the Republic of Tyva was carried out. The assessment of the quality of water resources was carried out in accordance with the criteria of the methodological recommendations "Control of the quality and safety of mineral waters by chemical and microbiological indicators" No. 96/225, approved by the Ministry of Health of Russia on 07.04.1997. The typification of water resources is given in accordance with GOST R 54316-2011 "Natural mineral drinking waters". RESULTS: The territory of the Republic of Tyva has the richest reserves of unique therapeutic hydro-mineral resources, and the existing features of landscape and climatic conditions determine the prospects for their widespread use. The surveyed areas are located on mid-mountain and low-mountain landscapes with favorable bioclimatic conditions for the organization of climate treatment and recreation, especially in the warm season. The prospects for the development of climate-balneological and climate-mud resorts in Tuva are shown, especially in terms of medical and health tourism. CONCLUSION: A detailed database has been developed on the components of the resort and recreational potential (bioclimate, mineral waters, therapeutic mud) of the treatment areas of Tuva. The data obtained formed the basis of proposals for updating the register of resorts and health-improving areas of the Siberian Federal District, which is formed on the basis of the results of many years of research.
Balneology , Mineral Waters , Health Resorts , Mineral Waters/therapeutic use , Russia , Siberia
OBJECTIVE: To study the effect of the course-based comprehensive rehabilitation using the therapeutic physical factors of the Belokurikha resort, including hydrokinesiotherapy in a pool with mineral water on the circadian rhythms of arterial pressure and its autonomous regulation in patients with arterial hypertension (AH) associated with chronic psychoemotional stress (CPES). MATERIAL AND METHODS: The study involved 83 patients with stage I-II grade 1-2 of AH, whose professional activities were associated with CPES. Each participant had 24-hours Holter blood pressure monitored, and cardiointervalography (CIG) was performed before and after the medical rehabilitation course. The rehabilitation complex of the main group (II) included medication therapy for AH, diet, morning hygienic gymnastics, manual massage, total magnet therapy, and hydrokinesiotherapy in a pool with mineral water. Patients in the comparison group (I) were exposed to similar therapeutic physical factors with identical parameters of the procedures, except hydrokinesiotherapy, which was replaced by full baths with mineral water. RESULTS: Medical rehabilitation using the therapeutic physical factors of the Belokurikha resort with hydrokinesiotherapy in a pool promotes a decrease in the activity of a sympathetic nervous system and increase of vagal effects contribute to the regulation of vital functions of the AH patients, associated with CPES, thus minimizing the frequency of abnormal daily profiles night-peaker and over-dipper to 12.5% and 1.78% of cases, respectively, and increasing the percentage of subjects with its normal type (dipper) to 57.1% (p=0.039). CONCLUSION: The study results show the benefits of hydrokinesiotherapy in a pool with mineral water as a part of the course-based comprehensive rehabilitation in patients with hypertension and chronic psychoemotional stress in terms of normalizing circadian rhythms of arterial pressure and optimizing the activity of higher autonomous centers, which largely determine the cardiovascular system performance in this setting.
Hypertension , Mineral Waters , Arterial Pressure , Autonomic Nervous System , Blood Pressure/physiology , Circadian Rhythm/physiology , Humans , Hypertension/therapy
BACKGROUND: The relevance of this study is determined by the need for the scientifically sound substantiation of the possibility for the use of acidic mineral waters in the treatment of digestive diseases taking into consideration their widespread application in ethnomedicine, in particular in the Republic of Tuva. AIM: The objective of the present study was to elucidate the gastroprotective action of acidic mineral water from the Azhyg-Sug source (Republic of Tyva) on the experimental animals as exemplified by the model of ulcerogenesis under the conditions of immobilization stress. MATERIAL AND METHODS: The experimental studies were carried out with the use of 32 white rats of the Wistar line. Ulcerogenesis was initiated by means of immobilization stress. We evaluated the pathomorphological characteristics of the gastric mucosa and the number of destructions based on the Pauls index. The state of the lipid peroxidation system and antioxidative protection were determined from the content of malon dialdehyde and reduced glutathione, extracellular catalase and superoxide dismutase activities in erythrocytes. RESULTS: The study has demonstrated that the mineral water from the Azhyg-Sug source slows down the development of the inflammatory and destructive necrotic processes in the mucosa of the stomach of albino rats. The depth of erosion in the animals receiving mineral water was 2.3 and 3.4 times lower than in the control animals (p≤0.05). The antioxidant effect of mineral water was confirmed by the 14-20% decrease of the MDA concentration as well as by the increase of the catalase and superoxide dismutase (SOD) activities by 21-25% and 20-30% respectively in comparison with the control animals. CONCLUSION: The Azhyg-Sug mineral water has the strong gastroprotective influence on the experimental animals having the induced neurogenic ulcer. One of the mechanisms underlying the gastroprotective action of the investigated mineral water arises from its ability to inhibit the processes of lipid peroxidation with the simultaneous enhancement of the activity of the antioxidant system of the organism.
Antioxidants/therapeutic use , Mineral Waters/therapeutic use , Stomach Ulcer/prevention & control , Animals , Disease Models, Animal , Protective Agents , Rats , Rats, Wistar
BACKGROUND: Notwithstanding the current abundance of the methodological approaches to the evaluation of the outcomes of medical rehabilitation, the criteria for the effectiveness of the combined influence of the curative physical factors are still inadequate and remain at variance with the principles of evidence-based medicine. AIM: The objective of the present study was to develop a method for the evaluation of the effectiveness of the rehabilitation activities in the patients presenting with the acute coronary syndrome following endovascular cardiac interventions. MATERIAL AND METHODS: This work is based on the results of a prospective single-center cohort-based clinical study involving the subjects who had undergone myocardial infarction following endovascular cardiac surgical interventions. The duration of the patient's participation in the study was 21 days. RESULTS: We have developed the integrative approach to the creation of the unified multi-criteria system for the evaluation of the effectiveness of the treatment of the patients presenting with cardiovascular diseases after percutaneous coronary interventions (PCI). In addition, the step-by-step description of this technology is presented. The algorithm for the calculation of the integrated health index and the evaluation of the overall effect of the rehabilitation activities was proposed based on the assessment of the clinical, laboratory, and functional indicators of the health status together with the psychological characteristics of individual patients. It is proposed to consider an integrated health index as a parameter for estimating the rehabilitation potential of the patients suffering from cardiovascular diseases after percutaneous surgical interventions. CONCLUSION: The proposed system for the evaluating of the effectiveness of comprehensive medical rehabilitation differs from analogous intellectual products in that it excludes the subjective interpretation of the severity of clinical symptoms associated with the concrete pathological process and makes impossible the arbitrary determination of the weight of the peculiar features of the patient's condition. Moreover, it allows to reduce the parameters of different types chosen as the criteria for the evaluation of the effectiveness of rehabilitation to the standardized values, to obtain an unambiguous numerical expression of the results of the rehabilitative treatment, and to compare the outcomes of the rehabilitation activities based at different treatment and prevention settings.
Cardiac Rehabilitation , Percutaneous Coronary Intervention/rehabilitation , Humans , Prospective Studies , Treatment Outcome
BACKGROUND: the creation of the efficient system of the spa and health resort-based health care for the population of the entire territory of the Russian Federation requires the systematic evaluation and protection of the natural resources of country as a basis for the further development of the health resort and recreation facilities in different regions. AIM: The objective of the present study was to estimate the possibilities of expansion of the health resort and recreational activities based on the rational exploitation of the natural resources of the medical-recreational and balneotherapeutic areas of the Krasnoyarsk Territory. METHODS: The inspection of the medical-recreational and balneotherapeutic regions of the southern part of the Krasnoyarsk Territory with the evaluation of the medicinal and raw materials resources of the spa and health resort facilities located in this area. The comprehensive assessment of the landscape and climatic conditions of the territory was performed in compliance with the methodological recommendations No 96/226 «The bioclimatic passport of the medical-recreational and balneotherapeutic region¼ approved by the Ministry of Health of the Russian Federation as of 7 February 1997. The quality of water bodies/sources was carried out in conformity with the criteria envisaged by the methodological recommendations No 96/225 «Quality and safety control of mineral waters based on their chemical and microbiological characteristics¼ approved by the Ministry of Health of the Russian Federation as of 7 April 1997. Water typing was performed in accordance with GOST R 54316-2011 «Natural drinking mineral waters¼. RESULTS: The medical-recreational and balneotherapeutic regions in southern part of the Krasnoyarsk Territory are notable for the great variety of mountainous, forest and steppe landscape forms with their favorable bioclimatic conditions and unique resources of therapeutic muds and mineral carbonic waters. The area is characterized by the great potential for the further development of the climatic spa and health resort facilities, and the improvement of the health care service for both children's and adult populations based on the rational use of the local landscape and climatic factors available at the territories occupied by the spa and health resort facilities of the balneotherapeutic profile. The prospects for the further expansion of medical and recreational tourism are discussed. CONCLUSIONS: This article was designed to systematize the available data characterizing the balneotherapeutic and recreational conditions of the medical-recreational regions of the southern part of the Krasnoyarsk Territory with special reference to the value of their natural resources, such as bioclimate, mineral waters, therapeutic muds, etc., for their inclusion in the registry of the areas possessed of the great health-improving potential based on the rational nature use and environmental management programs.
Balneology , Health Resorts , Humans , Mineral Waters , Russia
Prophylactic study among workers engaged into main production of Siberian chemical enterprise (Seversk city) revealed high frequency of cardiovascular risk factors (overweight, hypodynamia, dyslipidemia, arterial hypertension), low level of adaptational potential and integral somatic health parameter as prenosologic criteria of cardiovascular diseases. The results necessitate recommendations to supplement periodic medical examinations with studies aimed to reveal early criteria of health disorders, and determine priority directions to specify prophylactic measures in nuclear industry workers.
Cardiovascular Diseases/diagnosis , Extraction and Processing Industry , Occupational Diseases/diagnosis , Radiation Injuries/diagnosis , Adult , Cardiovascular Diseases/blood , Cardiovascular Diseases/prevention & control , Female , Humans , Male , Middle Aged , Occupational Diseases/blood , Occupational Diseases/prevention & control , Radiation Injuries/blood , Radiation Injuries/prevention & control , Risk Factors
The study was conducted on aircraft-building enterprise during production microcycle (before working shift start, during last working hour and in an hour after the shift end)--spectral analysis covered variability of heart rhythm in 70 male assembler riveters aged 25-59, divided into 2 groups in accordance with industrial equipment used. The group 1 used standard vibroinstrument, the group 2--pneumoinstruments with low vibration velocity parameters. Triple study during the working shift revealed in group 2 an adequate reaction of vegetative nervous system to vibration, in group 1 a negative trend was seen with centralization of regulatory processes and absence of adequate recovery in an hour after work.
Aircraft , Autonomic Nervous System Diseases/diagnosis , Manufacturing Industry , Occupational Diseases/diagnosis , Occupational Exposure/adverse effects , Vibration/adverse effects , Adult , Autonomic Nervous System Diseases/etiology , Humans , Male , Middle Aged , Occupational Diseases/etiology
It has been established that DNA, in addition to its basic functions (storage and realization of genetic information), also carries CpG-rich sequences having immunopotentiating properties. In this study we investigated the dynamics of the quantitative and qualitative characteristics of cell-free DNA (cfDNA) circulating in blood plasma of patients with acute ischemic stroke compared with the biomechanics of their blood samples flow, cerebral infarct volume and dynamics of neurological disorders. The results obtained revealed a new drag-reducing function of the circulating cfDNA and its important role in a regulation of blood flow hydrodynamic resistance in conditions of disturbed cerebral circulation. Moreover, our results showed a dependence of cerebral infarct volume and clinical picture dynamics on the plasma concentration of transcribed region of ribosomal repeat CpG-rich sequences (rDNA). It was established a new function of rDNA fragments circulating in the total pool cfDNK, i.e., generation of the intercommunication between blood and brain cells to induce neuroprotection in ischemic stroke.
Brain Ischemia/blood , DNA/blood , Genes, rRNA , Stroke/blood , Adult , Aged , Brain Ischemia/etiology , Brain Ischemia/physiopathology , Case-Control Studies , CpG Islands , DNA/genetics , Female , Hemodynamics , Humans , Male , Middle Aged , Stroke/etiology , Stroke/physiopathology
We have developed the method for the treatment of the patients presenting with arterial hypertension and concomitant chronic psychoemothional overtension. The method consists of the application of the baths containing the Siberian Stag velvet antler extracts in combination with exercise therapy and massage. A total of 35 patients with arterial hypertension and concomitant chronic psychoemothional overtension were enrolled in the study. It was shown that inclusion of the baths containing the Siberian Stag velvet antler extracts in the combined treatment of arterial hypertension and concomitant chronic psychoemothional overtension has positive effect on the parameters of the main homeostatic systems, enhances the working capacity of the patients, promotes their psychological stability, and increases the adaptive potential of the organism.
Affective Symptoms/rehabilitation , Antlers/chemistry , Baths , Complex Mixtures/administration & dosage , Hypertension/rehabilitation , Reindeer , Adult , Affective Symptoms/etiology , Affective Symptoms/physiopathology , Affective Symptoms/psychology , Animals , Chronic Disease , Complex Mixtures/chemistry , Exercise , Female , Humans , Hypertension/complications , Hypertension/physiopathology , Hypertension/psychology , Male , Massage , Middle Aged
This article is devoted to the history of one of the oldest Siberian health resorts known as "The Karachi Lake". It describes the stages of its development, the scientific component of the system of spa-and-resort therapy and medico-social rehabilitation of the patients. The detailed analysis of the mechanisms underlying the beneficial action of the natural therapeutic factors, cooperation with the leading research institutions, and the formation of the modern scientific and technical basis have strengthened the position of the resort on the market of the medical, health-promoting, and recreational services due to the development of the new activities in this field.
Balneology , Biomedical Research , Health Resorts/history , Rehabilitation , Balneology/history , Balneology/organization & administration , Biomedical Research/history , Biomedical Research/organization & administration , History, 19th Century , History, 20th Century , History, 21st Century , Humans , Lakes/chemistry , Rehabilitation/history , Rehabilitation/organization & administration , Siberia
The authors evaluated effects of antlers of Siberian stags on humoral homeostasis parameters in highly qualified athletes during contest period. Medication based on antlers of Siberian stags provides more balanced operation of energy supplying processes, maintains stable lipid metabolism, favors balance in "prooxidants - antioxidants" system.
Adaptation, Physiological , Antlers/chemistry , Biological Products/administration & dosage , Homeostasis , Physical Endurance , Reindeer , Adaptation, Physiological/drug effects , Adaptation, Physiological/physiology , Adolescent , Adult , Animals , Athletes , Dose-Response Relationship, Drug , Drug Monitoring/methods , Energy Metabolism/drug effects , Homeostasis/drug effects , Homeostasis/physiology , Humans , Lipid Metabolism/drug effects , Male , Physical Endurance/drug effects , Physical Endurance/physiology , Powders , Skating , Treatment Outcome
The authors performed gender analysis of efficiency caused by general bath containing antlers of Siberian stags in athletes engaged into winter sports. Male athletes demonstrated increased physical performance, low RBC membrane response to epinephrine, decreased cortisol level, higher testosterone level and longer time of breath-holding in Stange's test. Female athletes demonstrated no reliable changes in the mentioned parameters.
Adaptation, Physiological , Antlers/chemistry , Athletic Performance/physiology , Baths/methods , Biological Products/therapeutic use , Reindeer , Adaptation, Physiological/drug effects , Adaptation, Physiological/physiology , Animals , Athletes , Breath Holding/drug effects , Dose-Response Relationship, Drug , Drug Monitoring/methods , Erythrocyte Membrane/drug effects , Female , Humans , Hydrocortisone/blood , Male , Sex Factors , Skiing , Testosterone/blood , Treatment Outcome , Young Adult
This study included prognostication of the results of daily application of peloids for the treatment of the patients presenting with chronic bronchitis and obstructive pulmonary disease using a mathematical model. It was shown that the individualized selection of the patients for the daily application of peloid preparations taking into consideration the results of mathematical prognostication makes it possible to significantly improve the total efficacy of the treatment (up to 97.7%), accelerate the achievement of positive outcome of peloidotherapy, reduce by a factor of 4 the frequency of moderately severe balneoreactions, and increase the duration of the remission period by 3.5-4 months.
Balneology/methods , Bronchitis, Chronic/rehabilitation , Models, Biological , Humans
The objective of the present study was to estimate the influence of the products prepared from young not ossified antlers marals of Siberian red deer on the characteristics of the blood oxygen-supplying system in the athletes undergoing heavy physical loads during the contest season. It was shown that the use of such preparations promotes correction of humoral characteristics reflecting the development of iron-deficient conditions.
Antlers/chemistry , Athletes , Deer , Iron/blood , Oxygen/blood , Physical Endurance/drug effects , Tissue Extracts/administration & dosage , Adolescent , Adult , Animals , Humans , Male , Tissue Extracts/chemistry
The high brilliance of the AILES beamline at the SOLEIL synchrotron facility has been exploited for the study of the gas-phase vibrational spectra of weakly volatile organophosphorous compounds. The propagation of the synchrotron radiation in long path length gas cells allowed improvements in the sensitivity limits and spectral coverage compared with a previous study, performed by our group with conventional thermal sources. A ppm level detection in the entire IR domain up to terahertz (THz) frequencies has been realized for dimethyl methylphosphonate (DMMP), trimethyl phosphate (TMP), triethyl phosphate (TEP), and diethyl (2-methylallyl)phosphonate (DEMaP). In the present study, the assignment of the gas-phase vibrational and the conformational analysis of the two most stable conformers of DMMP and TMP have been extended to the torsional THz spectra in the 20-120 cm(-1) range. The improvement of the S/N ratio below 600 cm(-1) has permitted for the first time a gas-phase conformational analysis of the two weakly volatile and highly flexible TEP and DEMaP compounds. The experimental far-infrared (FIR)/THz spectra have been studied taking into account four low-energy conformers determined by means of high level of theory quantum chemistry calculations. Finally, due to its particularly low vapor pressure, the detection of gas-phase tributyl phosphate (TBP) in the FIR domain was unsuccessful. Nevertheless, the mid-IR/near-IR spectra of TBP recorded in a multipass cell heated to 355 K have been assigned with the harmonic vibrational predictions of the most stable conformer.
The study was made of therapeutic activity of silicon mineral water Tersinka inhalations on clinical symptoms, external respiration function and activity of inflammation in patients with chronic bronchitis and bronchial asthma as shown by biochemical markers of inflammation in the blood serum and nasal secretion. A correlation was found between treatment efficacy and concentration of sialic acids in the nasal secretion in pulmonological patients.
Mineral Waters/administration & dosage , Nasal Mucosa/metabolism , Respiratory Therapy/methods , Respiratory Tract Diseases/therapy , Administration, Inhalation , Adult , Aged , Aged, 80 and over , Asthma/metabolism , Asthma/therapy , Biomarkers/analysis , Biomarkers/blood , Bronchitis/metabolism , Bronchitis/therapy , Ceruloplasmin/analysis , Ceruloplasmin/metabolism , Female , Humans , Male , Middle Aged , Mineral Waters/therapeutic use , Muramidase/analysis , Muramidase/metabolism , Nasal Mucosa/chemistry , Pneumonia/metabolism , Pneumonia/therapy , Proteins/analysis , Proteins/metabolism , Respiratory Tract Diseases/metabolism , Sialic Acids/blood , Sialic Acids/metabolism
A modified method of determining the sialic acids by using Ehrlich's reagent and according to G. Sydow (1985) was worked out; the method is characterized by a higher sensitivity as compared to the unified methods of Hess and Svennerholm, which enables to process the nasal mucous lavage that has an essentially lower concentration of sialic acids than the blood serum. A clinical approbation of the modified method (in patients with bronchial asthma, and with obstructive and non-obstructive bronchitis) showed that it preserved the specificity typical of the original method and is sufficiently sensitive. Examinations of 12 healthy volunteers showed that the concentration of sialic acids in their lavage amounted to 0.110 +/- 0.012 mumol/L.
Nasal Mucosa/chemistry , Sialic Acids/analysis , Asthma/diagnosis , Biomarkers/analysis , Bronchitis, Chronic/diagnosis , Female , Humans , Male , Middle Aged , Therapeutic Irrigation
AIM: To assess therapeutic and prophylactic effect of large-dose cerebrolysin (15 ml/day for 28 days) in hypertensive and atherosclerotic patients with cognitive disorders. MATERIAL AND METHODS: Cerebrolysin was given annually (15 ml/day for 28 days) for 2 years to 42 patients in a randomized double-blind placebo-controlled study. The effect was stated by clinical status, neuropsychological and neurophysiological data. RESULTS: In mild disturbances of cognitive functions in patients with arterial hypertension and atherosclerosis courses of cerebrolysin with one-year interval produce stable improvement of subjective status, productivity of memory, attention and thinking which persist for at least a year after the course. The clinical data agree with positive trend in neurophysiological parameters of cognitive component of the response of evoked potentials P-300. CONCLUSION: A course of 28-day annual treatment with cerebrolysin (15 ml/day) of patients with mild defects of cognitive functions stabilizes the process, leads to regression of cognitive disorders predicting vascular dementia.
Amino Acids/therapeutic use , Arteriosclerosis/complications , Cognition Disorders/drug therapy , Hypertension/complications , Neuroprotective Agents/therapeutic use , Nootropic Agents/therapeutic use , Aged , Amino Acids/administration & dosage , Cognition Disorders/complications , Cognition Disorders/diagnosis , Cognition Disorders/prevention & control , Data Interpretation, Statistical , Double-Blind Method , Female , Follow-Up Studies , Humans , Male , Middle Aged , Neuroprotective Agents/administration & dosage , Neuropsychological Tests , Nootropic Agents/administration & dosage , Placebos , Time Factors
